Sirolimus is an immunosuppressant used with other medicines to prevent transplant rejection.
Take sirolimus regularly as directed with a glass of water.
If you are also taking ciclosporin (Neoral®), take sirolimus 4 hours after a ciclosporin dose.
Measure the liquid carefully with the syringe supplied, and add to a glass of water or orange juice (do not use grapefruit juice or paper/polystyrene cups). Stir well and drink straight away. To make sure you get the full dose, add some more juice to the glass and drink that too.
Take the missed dose as soon as possible. If it is close to the time for your next dose, skip the missed dose and carry on as normal. Do not take two doses at the same time.
Some medicines available without a prescription may react with sirolimus including:
Tell your pharmacist or doctor about all medicines or treatments that you may be taking, including vitamins, herbal products (e.g. echinacea, St John's wort) or recreational drugs.
|Side Effects||Recommended action|
Symptoms of allergy including: skin rash, itching, swelling, trouble breathing
Swollen lips, tongue, throat or face
Reduced number of blood cells that fight infections or help your blood to clot - symptoms include: fever, chills, sore throat or generally feeling unwell, or easy or unusual bruising or bleeding
Persistent dry cough
Symptoms of a blood clot including: sudden shortness of breath, swelling or pain in one leg
|Tell your doctor immediately|
Joint, muscle or bone aches and pains
Peeing more often, feeling thirsty
Swollen feet or legs
Increased blood pressure
|Tell your doctor|
Headache, trouble sleeping
Acne, nose bleeds
Changes in periods
Abdominal pain, constipation or diarrhoea, nausea
|Tell your doctor if troublesome|
If you notice any other effects, discuss them with your doctor or pharmacist.
This leaflet contains important, but not all, information about this medicine.
Prepared by the PILs Committee at Christchurch Hospital, Canterbury District Health Board, New Zealand. October 2020
For more general information about this sheet and its contents, see: What does a My Medicines sheet cover?
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My Medicines Patient Information Leaflets (PILs) contain important, but not all, information about the medicines they describe.
For more information about the sheets, see: What does a My Medicines sheet cover?
My Medicines is developed by a team at the Canterbury District Health Board. Our team is made up of doctors, pharmacists, and a non-medical person to help us keep to plain language. We also discuss our information with specialist health professionals or groups when needed